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Tanta University (2018)

Production of antimicrobial material from actinomycetes isolated from hot springs in Egypt

Soliman, Sara Attia Ahmed.

Titre : Production of antimicrobial material from actinomycetes isolated from hot springs in Egypt

Auteur : Soliman, Sara Attia Ahmed.

Etablissement de soutenance : Tanta University

Grade : Master of Science (MSc) in Microbiology 2018

The search for bioactive metabolites including novel antibiotic compounds from microbial sources for potential use in agricultural, pharmaceutical, and industrial applications has become more important due to the development of drug/multi-drug resistance in most of the pathogenic microbes. Researchers across the globe are aggressively searching for new, potent, sustainable, and broad- spectrum antimicrobial compounds from various sources including microbes. Actinomycetes are diverse group of Gram positive bacteria that usually grow by filament formation. Actinobacteria are widely distributed is both terrestrial and aquatic ecosystems, mainly in soil, where they play an essential role in recycling refractory biomaterials by decomposing complex mixtures of polymers in dead plants animals and fungi. Since hot spring environment differs greatly from terrestrial habitats, the biological characteristics of actinomycetes and their distribution are expected to be different from those of soil actinomycetes, Furthermore, the hot spring environment is proving to be a major source of new natural products, especially antimicrobial compounds, most notably those expressed by actinomycetes. Antibiotics and other bioactive compounds from actinomycetes are renowned for their antibacterial, antifungal, neuritogenic, anticancer, antialgal, antimalarial, and anti-inflammatory activities. In this study, twenty four actinomycete isolates were isolated on starch-nitrate agar medium from different hot springs in Egypt (Helwan,Sewa oasis, and Pharaoh’s bath hot spring). The isolates were screened for antimicrobial activity against eight multi-drug resistant bacterial species E.coli, P. mirabilis, P. aeruginosa, S. typhimurium, K. pneumonia, Staph.aureus, B. cereus, L. monocytogenes and six fungal species T. mucoides, C.albicans, C. glabrata, C. krusie, C. dublinesis and C. tropicalis by using wellagar diffusion method. Out of 24 isolates, the promising results were recorded by isolates act.17,act13, and act.4 against Staph. aureus, P. aeruginosa and C. tropicalis,therefore, they were selected for further work.

Présentation étendue (EULC)

Page publiée le 29 décembre 2020