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Banasthali Univesity (2013)

PROSPECTING BIOCOMPATIBLE CARBOHYDRATE POLYMERS FROM DESERT MICROORGANISMS FOR WOUND MANAGEMENT

PARWANI, LAXMI

Titre : PROSPECTING BIOCOMPATIBLE CARBOHYDRATE POLYMERS FROM DESERT MICROORGANISMS FOR WOUND MANAGEMENT

Auteur : PARWANI, LAXMI

Université de soutenance : Banasthali Univesity

Grade : Doctor of Philosophy (PhD) 2013

Sommaire partiel
Hydrogels, hydrocolloids, foams, film dressings, honey, collagen, alginate based dressings and antimicrobial dressings are based upon the concept of moist wound healing they accelerate the wound healing process and have been developed and are being regularly used by the developed countries. Most of these dressings, available in the market are either of synthetic origin or contain products of animal origin. Alginate, carrageenan, agarose, fucoidan based dressings are derived from seaweed polysaccharides. Use of cyanobacteria in wound management is a novel aspect as applicability of cyanobacterial exopolymer in the field of wound management is an unexplored area of research. Plant based biopolymer like that from Moringa oleifera pods though known for their medicinal values also remain unexplored for wound management. The gum from Acacia plant commonly known as gum arabic/gum acacia composed of arabinogalactans has been sparsely studied. In the present study cyanobacterial exopolymers along with two plant biopolymers viz. Moringa seed polymer and gum acacia have been explored and in vitro characterised for their potential in wound care. Synthesized hydrogels as PVA/plant biopolymer blends have been characterised in vitro and their wound healing potential has been established by in vivo studies on swiss albino mice models.
Twenty three exopolymer producing cyanobacterial forms isolated from arid region of Rajasthan and were explored for their wound healing potential. Moringa seed polymer and gum acacia were also prospected for their wound healing potential. All the studied biopolymers were thrombogenic and compatible for blood serum and plasma at their low concentrations. Based upon their hemolytic activity, only four cyanobacterial strains (three species of Anabaena and Tolypothrix tenuis) were selected for further studies. The Studied biopolymers were able to reduce blood coagulation time, APTT (12-41%) and PT (10-65%) and exhibited a high water absorption capacity (415-2588%). All the biopolymers were found to be non-cytotoxic for Vero cell line. They possessed inherent antibacterial activity against wound pathogenic organisms E.coli, B. licheniformis, S. aureus and P. aeruginosa and were biodegradable.

Présentation et version intégrale (Shodhganga)

Page publiée le 13 février 2021