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Accueil du site → Doctorat → Inde → 2018 → Screening and Identification of Secondary Metabolites Produced by Stress tolerant Penicillium Strains under Extreme Environmental Conditions

Babasaheb Bhimrao Ambedkar University (2018)

Screening and Identification of Secondary Metabolites Produced by Stress tolerant Penicillium Strains under Extreme Environmental Conditions

Jyoti

Titre : Screening and Identification of Secondary Metabolites Produced by Stress tolerant Penicillium Strains under Extreme Environmental Conditions

Auteur : Jyoti

Université de soutenance : Babasaheb Bhimrao Ambedkar University

Grade : Doctor of Philosophy (PhD) 2018

Sommaire partiel
Production of secondary metabolites by microorganisms in extreme conditions is well documented. Fungi are well-known for their ability to synthesize wide variety of small bioactive molecules called as secondary metabolites ; detrimental (toxins) and beneficial (pharmaceuticals) effects on human welfare (Keller, et al. 2005 ; GawasSakhalkar, et al. 2012). Due to these bioactive properties, many fungal secondary metabolites have been adopted by humans for their use as Pharmaceuticals such as antibiotics, cholesterol-lowering agents, tumor inhibitors and immune-suppressants for transplant operations (Keller, et al. 2005). The production of secondary metabolites by fungi may depend upon the nutrient availability, physical and environmental conditions. However, the production of secondary metabolites in extreme environmental conditions could be a new approach and may be an area of interest as the production of bioactive molecules may get modified and enhanced. The present study was an attempt to explore the potential aptitude of two Penicillium strains isolated from two different climatic zones, for the production of secondary metabolites under harsh environmental conditions such as, temperature, pH, salinity, heavy metal and nutrient stress. The identification of secondary metabolites produced by Penicillium strains were also studied. It is postulated that alterations in microbial membrane (protein, nucleic acids, lipid content) and production of secondary metabolites may occur under different environmental stress conditions, which has been analyzed in the present study by using FTIR, LC-MS, GC-MS, UV-Vis absorption and HPLC-MS techniques. However, several studies have documented about the production of different secondary metabolites under extreme environmental conditions, but their potential applications in biomedical field is a topic of our interest

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Page publiée le 5 février 2021