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Accueil du site → Doctorat → Inde → 1990- 1999 → In-vitro antimalarial and antiamoebic potential of plants of medicinal value present in the desert ecosystem : a case study from Rajasthan

Jawaharlal Nehru University (1999)

In-vitro antimalarial and antiamoebic potential of plants of medicinal value present in the desert ecosystem : a case study from Rajasthan

Sharma, Poonam

Titre : In-vitro antimalarial and antiamoebic potential of plants of medicinal value present in the desert ecosystem : a case study from Rajasthan

Auteur : Sharma, Poonam

Université de soutenance : Jawaharlal Nehru University

Grade : Doctor of Philosophy (PhD) 1999

Sommaire partiel
1. An extensive and exhaustive review (1912-1999) based on conventional botanical descriptions, phytochemistry of their extracts and scientific parameters of dose dependence in vivo and in vitro, of antimalarial and antiamoebic plants along with their common antiprotozoal features has been listed. 2. The ethnobotanical information was gathered by direct field interviews of old villagers, ladies, the professional singers (Barots) and local healers (Gunijis and Vaidyas) practicing traditional medicine in the last half century. The most commonly described antipyretic plant was Calotropis procera .. The intact buds and flowers, roots burnt in mud-pots, and latex beads picked up from the sand are being used in fever. Similarly the plant Commiphora wightii was chosen to test its antiamoebic activity based on its mention in ethnobotanical information (Sharma 1995). 3. C. procera is a wild weed while C. wightii is a conserved plant with some socioeconomic benefits. C. procera is distributed widely in nature and may be one of the only available medicinal plants in a desert ecosystem and finds a place in folklore. C. wightii has however found a limited place in the pharmaceutical market. 4. Since plants have been found active against one particular organism can possess a broad spectrum of antiprotozoal activity against other organisms, so both the plants C. procera and C. wightii were tested against P. falciparum and E. histolytica. These two pathogens which are prevalent in the region are also easier to cultivate in the laboratory. 5. The preliminary phytochemical screening for C. procera leaves, roots, stem, flower and bud extracts showed most commonly found classes of compounds, while with the gum-oleo resin extract of C. wightii the alkaloids were absent. Peroxides, commonly known to be present in other antimalarial plants like Artemisia were conspicuous by their absence in both these plants. 6. All the ten standard antimalarial drugs tested showed activity at 30 to 3000 times lower doses of IC50 (0.00032-4.914 f. !g/ml) for MRC P.f 20 and IC50 (0.0047-4.959 ).tg/ml) ) for MRC P.f 76. The individual variations between the chloroquine related drugs and artemisinin related drugs were not significant. However the Artemisinin related drugs showed a better dose response for MRC P.f. 76.

Mots clés : Environmental science Antimalarial, antiamoebic ecosytem desert

Présentation et version intégrale (Shodhganga)

Page publiée le 18 mars 2021