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Al Neelian University (2020)

Phytochemical Analysis and Some Pharmacological Activities of Adansonia digitata L. (Baobab) Fruit Pulp Extracts

Nafisa Abdelgadir Ahmed Abdelgadir

Titre : Phytochemical Analysis and Some Pharmacological Activities of Adansonia digitata L. (Baobab) Fruit Pulp Extracts

Auteur Nafisa Abdelgadir Ahmed Abdelgadir

Université de soutenance : Al Neelian University

Grade : Master in Pharmacognosy (M. Pharm), 2020

Résumé partiel
This study was done on different fruit pulp extracts of A. digitata (ventricose type). Fruit capsules were collected from El-Obeid (Northern Kordofan State) – Sudan. Solvents were : 96% Ethanolic, Petroleum ether (40-60 CO), Chloroform, Methanol, and Water. Giving percentage yields ; (11.7835% & 27.705%), (0.14%), (0.34%), (28.36%) and (43.10%) respectively. Ethanolic extract was prepared by modified maceration and Soxhlet process in order to screen and make comparison and preference between two processes. Phytochemical screening done for both extracts revealed presence of phenolics (flavonoids, tannins, coumarins), saponins, terpenoids and sterols with traces of alkaloids. All constituents were found more in Soxhlet than modified maceration extract. Other extracts were prepared sequentially by Soxhlet : pet. ether, chloroform, methanol and maceration in water for 24hrs. Phytochemical screening for the four extracts revealed that ; pet. ether and chloroform extracts constitute fatty derivatives (terpenoids and sterols) with appearance of flavonoids in chloroform extract. Other constituents were mutually present in methanolic and water extracts by remarkable presence of flavonoids in both, saponins in water and alkaloids just in water. Thin layer chromatography screening was done to make agreement with phytochemical results and were found agreed. In vivo and in vitro pharmacological experiments were done. The two ethanolic extracts were administered orally to hyerlipidemic rats for twenty-eight days by two once daily doses (200 & 400mg/kg.b.wt) from each maceration and Soxhlet extract. Four serum parameters (total Cholesterol, Triglycerides, LDL- Cholesterol, and HDL- Cholesterol) were measured three times, before beginning, after fourteen days and twenty-eight days of treatment. Both extracts significantly lowered the level of all parameters except HDL-C which was not affected.

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