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Universidade Federal do Rio Grande do Norte (UFRN) 2021

Avaliação toxicológica e mutagênica do extrato aquoso das folhas de Licania rigida Benth em associação aos seus efeitos protetores sobre o estresse oxidative

Batista, Débora

Titre : Avaliação toxicológica e mutagênica do extrato aquoso das folhas de Licania rigida Benth em associação aos seus efeitos protetores sobre o estresse oxidative

Auteur : Batista, Débora

Université de soutenance : Universidade Federal do Rio Grande do Norte (UFRN)

Grade : Mestrado em Ciências da Saúde 2021

Résumé
Medicinal plants present bioactive substances that help in the treatment of the most diverse diseases and their use for therapeutic purposes is as old as human civilization. In Brazil, the use of medicinal plants for primary health care is widespread due to its large plant biodiversity, low cost, easy access, and wide popular knowledge about their use. However, it is worth noting that most species used in traditional medicine do not present scientific studies proving their efficacy, safety, chemical composition, or possible toxicity. In this context, the species Licania rigida Benth belonging to the Chrysobalanaceae family is a plant species found in the semiarid northeastern Brazil, being used in folk medicine for the treatment of inflammatory processes and diabetes. However, despite its use, there are few studies to validate its pharmacological and toxicological potential. As a result, the objective of this study was to evaluate the toxicological properties of the aqueous extract of Licania rigida through standardized methods of acute and subchronic oral toxicity, mutagenicity and cytotoxicity, as well as its possible protective effect against oxidative stress. The extract did not show any toxic or genotoxic effect in the in vivo and in vitro assays after exposure to different concentrations. With regard to the antioxidant effect, the extract exhibited a possible protective effect by decreasing the level of malondialdehyde (MDA) in treated animals ; no significant changes were observed for reduced glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPX) levels. Therefore, it is proposed that Licania rigida leaf extract may become a future herbal medicine, however, further studies are needed to validate its pharmacological application and for the development of new herbal formulations.

Mots Clés  : Plantas medicinais ;Toxicidade;Estresse oxidativo ;Fitoterápico

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Page publiée le 19 décembre 2021