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UniPID – Finnish University Partnership for International Development (2018)

Occurrence, Sources and Prevention of Antimicrobial Resistance in West Africa – Following the flow of AMR genes between humans, animals and environment

West Africa Antimicrobial AMR

UniPID – Finnish University Partnership for International Development

Titre : Occurrence, Sources and Prevention of Antimicrobial Resistance in West Africa – Following the flow of AMR genes between humans, animals and environment

Pays/Région : Afrique de l’Ouest

Durée : 1.3.2018 - 1.2.2000

Résumé
Antibiotics have made it possible for people to live longer, healthier lives. Antimicrobial resistance, however, is an increasing problem, especially in low-resource settings. This project will employ a range of methods from microbiology, clinical medicine and sociology to produce new knowledge about how AMR genes spread especially in poor West African regions, in areas where local capacity to address AMR is lagging behind, and identify ways to curb the spread of AMR. This knowledge can be utilized in national and international health policy and medical research.

Présentation
Antimicrobial resistance (AMR) is a global threat to human health. It has increased rapidly, especially in developing countries which lack controlled antibiotic policy, and have poor infrastructures enabling the flow of AMR genes between the environment, animals and humans. The struggle against AMR calls for novel tools which only can be found through deeper understanding of the flow of AMR genes across the community. The present study focuses on the flow of AMR genes in West Africa, a region with extensive gaps in data, joining environmental, microbiological, sociological, and medical expertise to explore the evolution and transfer of AMR genes between water, soil, animals, food, and humans (One Health approach).

In this project, written in equal collaboration with partners based in West-African research institutes, we propose to explore AMR gene flow using very advanced research methods, such as whole-genome sequencing. The study is harnessed for strengthening the capacity in regions desperately needing support in their efforts against AMR and, at the same time, providing valuable data for deeper understanding of the flow of AMR genes across the community. We aim to respond to local needs as identified by the project partners. Our microbiological and sociological approaches will lead to new knowledge about the spread of AMR genes, combining the key knowledge of the West African researchers to the new methods of Nordic researchers. We will explore various AMR genes in the environment (e.g. waste and irrigation waters, animal faeces), isolate E. coli pathogens, from animal faeces and humans, and generate understanding of the social practices that drive their spread. Cutting-edge research will be conducted in the region with the support of the international partners working on AMR, thus renewing current understanding of AMR and its evolution

Institution : University of Helsinki Department of Microbiology Helsinki, Finland

Partenaires  : University of Abomey-Calavi (Benin), University of Ouaga (Burkina Faso), Centre d’infectiologie Charles Mérieux (Mali)

Financement : Academy of Finland
Project budget 1-2 million euros :

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