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sur le développement des zones arides et semi-arides

Titre : Phytochemical and Biological Studies of Echinops macrochetus

Auteur : Zamzami, Taghreed Abduljalee

Université de soutenance : King Abdulaziz University

Grade : Master Thesis 2020

Résumé
Two new rare sesquiterpene glycosides, macrochaetosides A (3) and B (4), together with two known metabolites : stigmasterol (1) and cyclostenol (2) were separated from the CHCl3 fraction of the aerial parts of Echinops macrochaetus Fresen (Asteraceae). Their chemical structures were established on the basis various spectroscopic methods in addition to mass spectrometry and comparison with literature data. Moreover, the cytotoxic activity of these metabolites was assessed towards MCF-7, HepG2, and HCT-116 tumour cell lines using sulphorhodamine B assay (SRB). Compounds 2 and 3 showed a potent cytotoxic profile towards all tested cell lines with IC50s 2.1, 2.9, and 3.6 µM and 1.9, 3.3, and 2.3 µM, respectively. However, 4 exhibited cytotoxic activity against MCF-7 with IC50 6.9 µM. 

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