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Accueil du site → Doctorat → Royaume-Uni → 2007 → Diploid and haploid markers and their distributions in sample populations from Dubai, South Arabian Peninsula and Iran

University of Newcastle Upon Tyne (2007)

Diploid and haploid markers and their distributions in sample populations from Dubai, South Arabian Peninsula and Iran

Alshamali, F

Titre : Diploid and haploid markers and their distributions in sample populations from Dubai, South Arabian Peninsula and Iran

Auteur : Alshamali, F

Université de soutenance : University of Newcastle Upon Tyne

Grade : Doctor of Philosophy (PhD) 2007

Résumé
Five sample populations, four from the Southern Arabian Peninsula ; Dubai Nationals, Omani, Saudi Arabian and Yemeni, and Iranian were typed for 15 autosomal and 11 Y chromosome Short Tandem Repeats (STRs). A population sample of Dubai Nationals was typed for the entire mtDNA control region. Autosomal STR allele frequencies were calculated, data were tested and several statistical parameters defined. The autosomal STR data could be used for both forensic and paternity testing. The data also support the use of the Fst value of 0.01 for correction of population substructure. The genetic distance between these populations was measured and relatedness determined. The Y-STR haplotype diversity and shared haplotypes were determined and independence of Y-STR and autosomal STRs tested. The results support the conclusion that autosomal STR frequencies could be multiplied by Y-STR haplotype to determine the rarity of a match of a profile. The most powerful Y-STR loci markers were defined. The data has been compared on a global level including those in the YHRD database and published data. Analysis of Molecular Variance (AMOVA) showed little significant differences between these populations and a larger difference obtained in comparison to other groups. Genetic distances were measured for the same populations. The entire control region of the mitochondrial DNA of 231 Dubai Nationals has been sequenced. Standard diversity measures were determined and mtDNA haplogroups defined. The results showed a high diversity. The genetic component of Dubai population was determined. Data were compared globally with published data. The data provides an extended and reliable database for both forensic and population genetic studies.

Présentation (EThOS)

Accès au document : Proquest Dissertations & Theses

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