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University of Arizona (1978)

Phytochemical investigation of Croton californicus family Euphorbiaceae

Luzbetak, Doris Janet

Titre : Phytochemical investigation of Croton californicus family Euphorbiaceae

Auteur : Luzbetak, Doris Janet

Université de soutenance : University of Arizona

Grade : Master of Science (MS) 1978

Résumé
The ethanol extract of the roots, stems, leaves, flowers, and fruits of Croton californicus family Euphorbiaceae demonstrated antileukemic activity against the P-388 lymphocytic leukemia test system in mice. The crude ethanol extract was fractionated by a series of solvent partitions and extraction. The use of column chromatography and crystallization techniques led to the isolation of the following three compounds : (-)-hardwickiic acid, 1-triacontanol, and (-)-methyl barbascoate. The compounds were identified by .a combination of physical methods, including infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectroscopy, In addition, melting and mixed-melting point determinations as well as carbon, hydrogen analyses provided further evidence for the proposed structures. The structure of hardwickiic acid was confirmed by the preparation of a known derivative The observed optical rotation Established hardwickiic acid as the levorotatory isomer. :

Mots clés : Antineoplastic agents. ; Euphorbiaceae.

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