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University of the Western Cape (2009)

Chemical and biological investigation into some selected African indigenous medicinal plants

Babajide, Jelili Olalekan

Titre : Chemical and biological investigation into some selected African indigenous medicinal plants

Auteur : Babajide, Jelili Olalekan

Université de soutenance : University of the Western Cape

Grade : Philosophiae Doctor - PhD (Chemistry) 2009

Résumé
African medicinal plants are commonly used throughout Africa to treat a variety of ailments including wounds and ulcers, cough and chest complaints, gingivitis, fever and gonorrhoea, indication all related to infection and inflammation. In screening several plant species from an inventory of common medicinal plants from both South and West Africa for diverse medicinal purposes, 6 plants were selected because of their interesting and useful ethnomedicinal values. These plants are (1) Piliostigma reticulatum from the family Caesalpiniaceae, (2) Cissampelos capensis (family : Menispermaceae) (3) Geranium incanum (family : Geraniaceae) (4) Gethyllis gregoriana, (5) Gethyllis multifolia and (6) Gethyllis villosa. The three Gethyllis species belong to the Amaryllidaceae family. This study attempt to relate specific constituents present in these plants with their widespread ethnomedicinal uses. The extractions were carried out using broad spectrum of solvents (hexane, dichloromethane, ethyl acetate, methanol and water). Fractionation was carried out using standard chromatographic techniques. A total of thirty seven (37) compounds were isolated from three of the plants namely : P. reticulatum, C. capensis and G. incanum while only extractions were carried out on the Gethyllis species. Total of 18 isolates were characterised and their structures were unambiguously established by spectroscopic methods including infrared and ultraviolet spectroscopy, high resolution mass spectrometry and one- and two-dimensional nuclear magnetic resonance experiment.

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Page publiée le 26 décembre 2018, mise à jour le 8 janvier 2019