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Technical University of Dortmund (2018)

Phytochemical and Biological Investigation of Jatropha pelargoniifolia Roots Native to the Kingdom of Saudi Arabia

Aati, Hanan Yahya

Titre : Phytochemical and Biological Investigation of Jatropha pelargoniifolia Roots Native to the Kingdom of Saudi Arabia

Auteur : Aati, Hanan Yahya

Université de soutenance : Technical University of Dortmund

Grade : Dr. rer. nat. 2018

Résumé partiel
Reviewing the current literature for the phytochemical importance of the plants belonging to genus Jatropha revealed broad range of secondary metabolites isolated such as, diterpenoids, triterpenoids, non-conventional coumarino-lignoids, alkaloids, coumarins, flavonoids, cyclic peptides and steroids. This is indeed a reflection on the versatility of the enzymatic system present in the plants belonging to the family Euphorbiaceae but nothing was reported regarding pelargoniifolia species. Thus, it was of interest to explore the active constituents and biological importance for the titled plant which is used traditionally to cure ulcers and wounds in Ethiopia and Saudi Arabia. In vivo and in vitro studies were carried out to evaluate the potential hepatoprotective, antinociceptive, anti-inflammatory and antidiabetic/hypoglycemic effects of the total alcoholic extracts of aerial parts and roots of J. pelargoniifolia and J. glauca species in comparison to those of standard clinical drugs. As the result, the roots of J. glauca showed higher hepatoprotective and antinociceptive (63.85%) activities in comparison to indomethacin (69.87%). In addition, the root extracts from J. pelargoniifolia exhibited greater anti-inflammatory (50.63%) and hypoglycemic (37.98%) activities when compared with phenylbutazone (64.63%) and glibenclamide (51.57%), respectively. Finally, extracts from the aerial parts of J. glauca showed significantly higher anti-diabetic activity in mice with alloxan-induced diabetes (39.93%) when compared with glibenclamide (47.13%). Moreover, the chemical composition of the essential oil separated from J. pelargoniifolia roots was determined via GC-FID, resulting in isolation of 80 compounds representing 99.99% of the total oil constituents. Among these, 77.31% were sesquiterpenes, 14.62% were fatty acids, 7.21% were other components (i.e., phenolics, hydrocarbons, etc.), and 0.85% were monoterpenes. Then, the essential oil was evaluated for its potency as an anti-inflammatory, antioxidant, antipyretic, and antinociceptive agent by in vivo and in vitro models. The obtained results demonstrated that the investigated essential oil of J. pelargoniifolia roots could be used as a natural remedy for their anti-inflammatory, antinociceptive, antipyretic, and antioxidant effects.

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